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KMID : 0377619670120010075
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Korean Jungang Medical Journal
1967 Volume.12 No. 1 p.75 ~ p.80
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Vi And O Antibodies of Salmonella in Humman Sera
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Lee, Jae Koo/李在九
Oh, Hyun Sook/Choi, Hyun Ho/Kim Young Kwon/Doki Chun/吳賢淑/崔鉉浩/金永權/全燾基
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Abstract
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Enteric fever due salmonella, even nowadays, is not a rare disease in Korea, and
a great number of epidemic and sporadic incidents is reported every year. A brief report on the distribution of salmonella in Korea from 1952 to 1963 was presented1), and most of the enteric fevers in recent years are known to be due to Salmonella typhi. As the main source of the spread of typhoid fever is due to carriers, an important means of controlling this disease is the detection of carriers among the general population.
The bacteriological method is generally used for the detection of carriers, but the
significance of Vi antibody detection was also emphasized as a simple and practical
means 2~6. Bhatnagar et al. 7) recommended the use of Vi 1 strain of S. typhi for
Vi agglutination, but the results obtained by many workers differ widely in the percentages of carriers detected and in titers of reactions obtained with sera of apparently normal people. Vi hemagglutination reaction was studied with heated extract of Vi cultures of S. typhi. for sensitization of erythrocytes by Staack and Spaun 4), and then with purified Vi antigen by Landy and Lamb 8). The latter showed that the hemagglutination reaction provided a highly sensitive measure for Vi antibody detection and was useful for the detection of Vi antibody in carrier’s sera. Many workers believe that most promising means for the detection of carriers is a hemagglutination reaction using erythrocytes sensitized with purified Vi antigen 4,5). However, Vi hemagglutination reaction was found to be unsatisfactory for this purpose by Anderson (9). More recently Cooper and Singh 10) reported that this reaction is of little value in determining the typhoid carrier because of the increasing false Vi positivity in normal human sera and discussed the nature of antibodies in false and true Vi reactors.
The present study was undertaken to determine the significance of Vi hemagglutination reaction for the detection of typhoid carriers, and to know the relationship between Vi and 0 antibody titers in sera of patients as well as in normal persons.
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KEYWORD
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